CONTACTS 

SUBJECTS
Hyperthermia Cancer Treatment FDA Approved Alternative Chemotherapy

0803 -
0803 -    ..
0804 - Summary/Objective
0805 -
080501 - Follow up ref SDS 9 0000, ref SDS 8 0000.
080502 -
080503 -
080504 -
080506 -  ..
0806 -
0807 -
0808 - Progress
0809 -
080901 - Background on treatment for Millie's 6th relapse of IBC is reported on
080902 - 090127. ref SDS 8 MN5I
080904 -  ..
080905 - During the meeting at UCSF today Doctor Rugo sent a letter to Kaiser
080906 - recommending treatment with hyperthermia and Doxil provided in the
080907 - Radiation Oncology Department.
080908 -
080909 -            [On 090130 Millie's letter to the medical team reports
080910 -            Doctor Rugo's prescription for treating Millie's IBC with
080911 -            IBC and Doxil. ref SDS 10 TZ6H
080913 -  ..
080914 - This evening research on the Internet yielded...
080916 -         ..
080917 -        Hyperthermia Endorsement and Source Treatment IBC
080918 -        Endorsement and Source Hyperthermia Treatment IBC
080919 -
080920 -        Breastcancer.org
080921 -        Discussion Boards
080922 -
080923 -              http://community.breastcancer.org/member/77404/profile
080925 -         ..
080926 -        Jan 9, 2009 11:02 pm   cornfieldheiress wrote:
080928 -         ..
080929 -        IBC can be so stubborn, I refused masectomy because it had
080930 -        already spread to my neck.  I opted for hyperthermia combined
080931 -        with low-dose radiation in LA.  They have high success rate
080932 -        with ibc and some other cancers.  Non-invasive.  No chemo.
080933 -        We'd get one tumor down and another would pop up but we stayed
080934 -        the course and killed the beast!!!!  Hope this info helps
080935 -
080936 -            [On 090203 Millie's letter to medical team cites research
080937 -            showing good chance for hyperthermia treatment to restore
080938 -            local control recovering from 6th relapse of IBC.
080939 -            ref SDS 14 YQ6V
080941 -             ..
080942 -            [On 090220 0157 Millie's letter asks medical team for
080943 -            metrics used at UCSF for evaluating recovery from IBC that
080944 -            signals treatment with radiation and hyperthermia can end.
080945 -            ref SDS 19 RZ7N
080947 -             ..
080948 -            [On 090312 0800 meeting with Doctor Hsu and Chris seemed to
080949 -            indicate there are no "metrics" to evaluate duration of
080950 -            radiation and hyperthermia treatment to recover from IBC;
080951 -            Millie was given the maximum radiation she could tolerate
080952 -            based on prior treatments in 2002, and hyperthermia
080953 -            treatments were given for the same duration, with
080954 -            expectation this will have the optimum possible recovery
080955 -            from IBC. ref SDS 22 NV66
080957 -             ..
080958 -            [On 090312 0800 meeting with Doctor Hsu and Chris seemed to
080959 -            indicate side effects of radiation and hyperthermia are
080960 -            similar to IBC symptoms, so nobody can assess recovery from
080961 -            IBC for several weeks, event months after ending treatment,
080962 -            so how can treatment continue to until all IBC is resolved,
080963 -            unless multiple phases of treatment are given, and that
080964 -            conflicts with practice that patients have limited
080965 -            tolerance for radiation. ref SDS 22 F962
080967 -             ..
080968 -            [On 090412 2241 Millie reports to medical team that IBC
080969 -            popped up after completing radiation and hyperthermia was
080970 -            completed on 090317, and this occurred along a neat line at
080971 -            the perimeter of treated areas on the left arm. ref SDS 25
080972 -            9S8Y
080974 -             ..
080975 -            [On 090415 1519 Doctor Johnson reported another IBC patient
080976 -            at Kaiser suffered recurrence along the line of radiation
080977 -            and hyperthermia treatments, similar to Millie. ref SDS 26
080978 -            E042
080979 -
080980 -
080981 -
080983 -  ..
080984 - Valley Cancer Institute (VCI) Hyperthermia Practice
080985 -
080986 - Website explains hypethermia treatments...
080987 -
080988 -              http://vci.org/Default.htm
080989 -
080990 - ...located in Los Angeles; may be related to report in the record
080991 - above on successful treatment for IBC in LA. ref SDS 0 OI6N
080992 -
080994 -  ..
080995 - Another paper published in Proceedings of the XXVII ICHS International
080996 - Meeting, October 27-28, 2005, Florence, Italy.
080998 -  ..
080999 - Published in the German Journal of Oncology, (Deutsche Zeitschrift
081000 - f�r Onkologie) 2006, 38: 116-122.
081001 -
081002 -            Holistic Alternate Cancer Treatment Hyperthermia
081003 -             ..
081004 -            THERMORADIOTHERAPY WITH CURATIVE INTENT - BREAST,
081005 -            HEAD AND NECK AND PROSTATE TUMORS
081006 -
081007 -            AMES I. BICHER, M.D., NAZAR Al-BUSSAM, M.D. and RALPH S.
081008 -            WOLFSTEIN, M.D.
081009 -
081010 -            Valley Cancer Institute, Los Angeles, California U.S.A.
081011 -
081012 -               [On 090202 called VCI and set call with Doctor Al-Bussam
081013 -               on how soon Millie can get hyperthermia treatment at
081014 -               VCI. ref SDS 11 856F
081016 -                ..
081017 -               [On 090202 Doctor Al-Bussam advised well ordered record
081018 -               on 090121, ref SDS 7 NU5H, enabled timely review of
081019 -               Millie's complex patient history, ref SDS 12 8488; and,
081020 -               that accurate understanding enabled determining Millie
081021 -               can get treatment for cancer in time to be effective.
081022 -               ref SDS 12 OE4F
081024 -                ..
081025 -               [On 090203 medical team at Kaiser and UCSF asked for
081026 -               opinion on accepting VCI offer to provide hyperthermia
081027 -               treatment tomorrow on 090204 in time to be effective for
081028 -               Millie to recover from IBC compared to UCSF offer to
081029 -               delay treatment 3 weeks; and notes preference to work
081030 -               with UCSF if schedule can be advanced to current week in
081031 -               order to benefit from practice synergy. ref SDS 13 IS4R
081033 -                ..
081034 -               [On 090205 0830 meeting with Doctor Hsu at UCSF receive
081035 -               explanation of hyperthermia. ref SDS 16 T55M
081037 -                ..
081038 -               [On 090220 1548 paper received from UCSF describes
081039 -               hyperthermia combined with ionizing radiation provides
081040 -               effective treatment even for mutated cancer cells that
081041 -               resist treatment with chemotherapy. ref SDS 20 00FS
081042 -               Since hyperthermia combined with radiation and/or
081043 -               chemotherapy, ref SDS 20 0129, "kills" cancer cells,
081044 -               ref SDS 20 00EI, this does not seem to fit the model of
081045 -               "palliation" as mere relief from suffering while cancer
081046 -               progresses toward near term demise. "Killing" cancer
081047 -               cells through heat sounds like aggressive curative
081048 -               therapy. ref SDS 20 GK6F
081049 -
081050 -
081051 -
081053 -  ..
081054 - IBC Hyperthermia Low Dose Radiation and Chemotherapy Effective
081055 - Hyperthermia Applied Using Microwave Technology and Low Dose Radiation
081056 -
081057 - VCI has a professional paper on materials and methods using microwave
081058 - technology for hyperthermia treatments for IBC...
081059 -
081060 -              http://vci.org/inflamma.htm
081062 -         ..
081063 -        [On 090202 called to investigate VCI alternate vendor for
081064 -        treatment with hyperthermia in time for Millie to recover from
081065 -        6th relapse of IBC. ref SDS 11 SP6H
081067 -     ..
081068 -    An FDA approved alternative inflammatory breast cancer treatment
081070 -     ..
081071 -    Thermoradiotherapy Treatment For Localized Inflammatory Breast
081072 -    Cancer
081073 -
081074 -        [On 090205 0830 Doctor Hsu at UCSF changes plan for treating
081075 -        Millie's IBC from hypethermia with Doxil chemotherapy to lower
081076 -        dose radiation with hyperthermia. ref SDS 16 EY5F
081078 -         ..
081079 -        [On 090218 1205 Millie's letter to the medical team requests
081080 -        explanation of treatment plan using hyperthermia and radiation
081081 -        for recovering local control of IBC. ref SDS 17 TH5W
081083 -         ..
081084 -        [On 090219 during meeting with Doctor Hsu and Chris at UCSF
081085 -        requested medical orders for Millie's ratiation and
081086 -        hyperthermia treatments, similar to Chemotherapy Orders
081087 -        issued to the Infusion Clinic for Millie's care the past 2
081088 -        years. ref SDS 18 4254
081090 -         ..
081091 -        [On 090220 0157 Millie's letter to the medical team
081092 -        confirms request today for an explanation of the treatment
081093 -        plan, including the doctor's orders for radiation and
081094 -        hyperthermia treatments, similar to Chemotherapy Orders
081095 -        Millie received for care in the Infusion Clinic.
081096 -        ref SDS 19 EA4Q
081098 -         ..
081099 -        [On 090220 1548 paper received from UCSF describes hyperthermia
081100 -        combined with ionizing radiation provides effective treatment
081101 -        even for mutated cancer cells that resist treatment with
081102 -        chemotherapy. ref SDS 20 00FS  Since hyperthermia combined with
081103 -        radiation and/or chemotherapy, ref SDS 20 0129, "kills" cancer
081104 -        cells, ref SDS 20 00EI, this does not seem to fit the model of
081105 -        "palliation" as mere relief from suffering while cancer
081106 -        progresses toward near term demise. "Killing" cancer cells
081107 -        through heat sounds like aggressive curative therapy.
081108 -        ref SDS 20 GK6F
081110 -     ..
081111 -    James I. Bicher, M.D., Ralph S. Wolfstein, M.D., Tressia Keen,
081112 -    M.N., Sylvia Carter, Ph. D.
081114 -     ..
081115 -    Valley Cancer Institute, Los Angeles, California
081117 -  ..
081118 - VCI says in part...
081119 -
081120 -            Inflammatory breast cancer is more aggressive than other
081121 -            types of breast cancer ; indeed, it is one of the most
081122 -            aggressive of all neoplasms.
081123 -
081124 -            The best treatment for primary inflammatory breast cancer
081125 -            is multimodality, as described in several reports in the
081126 -            medical literature. These reports are quite consistent,
081127 -            with no recurrence in about a third of patients following
081128 -            chemotherapy, radiotherapy and mastectomy. Inflammatory
081129 -            chest wall recurrence of breast cancer is an even more
081130 -            devastating problem with essentially no possibility of
081131 -            control using chemotherapy and/or radiotherapy. This
081132 -            problem occurs about 20-30% of treated patients, within 24
081133 -            months of the initial treatment.
081134 -
081135 -               [On 090312 0800 UCSF prescribed multimodality using
081136 -               radiation and hyperthermia for Millie, because IBC was
081137 -               was very severe by the time treatment could be given.
081138 -               ref SDS 22 E65L
081140 -             ..
081141 -            MATERIALS AND METHODS
081143 -             ..
081144 -            Radiotherapy was delivered by linear accelerator, using
081145 -            bolused medial and lateral tangential fields. Several
081146 -            patients required additional fields for disease extending
081147 -            around to the back. A total 2-4 Gy in daily fractions of
081148 -            80-150 cGy was delivered depending on previous radiation
081149 -            dose and time since previous radiotherapy. One patient
081150 -            received a full course of 5.6Gy.
081151 -
081152 -               [On 090202 Nash at VCI explains doctors use PET/CT
081153 -               scans to layout IBC fields for hyperthermia treatment.
081154 -               ref SDS 11 CG6L
081156 -             ..
081157 -            Hyperthermia was given within one hour of each radiation
081158 -            treatment. patients required at least two hyperthermia
081159 -            fields, usually three or four, with two fields treated
081160 -            daily on a rotating schedule.  Most fields were treated by
081161 -            micro-wave (Celsion Corporation (former Cheung
081162 -            Laboratories) System 100, 915 MHz).  In those patients with
081163 -            massive breast tumor ultrasound was used (Labthermics
081164 -            Technologies, Sonotherm 1000, 1MHz and 3MHz).  Each
081165 -            hyperthermia treatment was of one hour duration to each
081166 -            field.  On average each patient required 3-4 treatment
081167 -            fields to cover the entire disease area.  Each field
081168 -            received 18-25 hyperthermia treatments.
081170 -  ..
081171 - Continuing in part from abstract reporting on study...
081172 -
081173 -            Response rate was gratifying.  Ninety percent (90%) of the
081174 -            fields responded to the combined treatment, with complete
081175 -            disappearance of the inflammatory process in 80% of the
081176 -            treated areas.  There was only four recurrences in the
081177 -            areas of complete response, while areas that responded
081178 -            partially showed regrowth within 3 months of treatment.
081179 -            Side effects were minimal, in the form of 6 first degree,
081180 -            superficial burns.  There was no correlation between the
081181 -            response rate and the radiation dose.
081182 -
081183 -                [On 090326 0054 Millie's letter to medical team cites
081184 -                research on favorable response to hyperthermia
081185 -                treatment to recover from IBC. ref SDS 23 6A5S
081187 -  ..
081188 - An enhanced MRI indicates imaging technology provides a direct metric
081189 - for evaluating response to treatment recovering from IBC
081190 -
081191 -              http://vci.org/inflcase2.htm
081192 -
081193 -            Enhanced MRI. Arrows point at area of Inflammatory Breast
081194 -            Cancer involvement ( yellow areas ).
081196 -  ..
081197 - Evaluating response to treatment with enhanced MRI imaging technology
081198 - may support treatment planning, which has been difficult in Millie's
081199 - patient history.  On 050107 the surgeon said left breast surgery could
081200 - not be done because there was no way to determine a surgical boundary
081201 - to remove IBC infected tissue. ref SDS 2 UM6I  On 050727 the surgeon
081202 - approved left breast surgery based on visual findings that IBC had
081203 - been totally eliminated by treatment with capecitabine and Taxotere.
081204 - ref SDS 3 YY7F  Surgical boundaries for a "wider than normal"
081205 - mastectomy were based on memory of prior observations. ref SDS 3 JV5J
081206 - After surgery on 051021 the doctor was hopeful that "wider than
081207 - normal" surgical boundary based on memory of IBC observations 10
081208 - months earlier was effective. ref SDS 4 E74F  On 060711 the primary
081209 - care physician diagnosed IBC relapse, ref SDS 5 025H, indicating
081210 - visual observation of IBC can be problematic.
081212 -  ..
081213 - Obvious question may be why radiation, hyperthermia and enhanced MRI
081214 - materials and methods have not been presented previously as options
081215 - for treating Millie's IBC.  Research on 040517 listed radiation, but
081216 - not hyperthermia nor MRI to determined the scope of IBC to treat.
081217 - ref SDS 1 JK94
081219 -                ..
081220 -               [On 090203 Millie's letter to medical team cites
081221 -               research showing good chance for hyperthermia treatment
081222 -               to restore local control recovering from 6th relapse of
081223 -               IBC. ref SDS 14 YQ6V
081225 -                ..
081226 -               [On 090220 0157 Millie's letter asks UCSF about metrics
081227 -               that will assess recovery from IBC after radiation and
081228 -               hyperthermia. ref SDS 19 EA5P and ref SDS 19 EA5T
081230 -                ..
081231 -               [On 090310 Millie's letter with agenda for meeting at
081232 -               UCSF on 090312 for evaluating response to treatment
081233 -               cites CA 15-3 as only metric of IBC infection.
081234 -               ref SDS 21 O63T
081236 -                ..
081237 -               [On 090312 0800 examination at UCSF radiation oncology
081238 -               department does not discuss using enhanced MRI for
081239 -               metric evaluating recovery from IBC after treatment with
081240 -               radiation and hyperthermia. ref SDS 22 BY8L
081242 -                ..
081243 -               [On 090330 1200 Doctor Hsu indicated that weakness of
081244 -               visual examiantion for evaluating response to radiation
081245 -               and hyperthermia treatment recovering from IBC has will
081246 -               work better than enhanced MRI in Millie's case.
081247 -               ref SDS 24 LO5N
081248 -
081249 -
081250 -
081251 -
0813 -

SUBJECTS
Treatment Chemotherapy Cancer Cells Test Biopsy Specimen in Laborato

1103 -
110401 -  ..
110402 - Cancer Laboratory Test Specimen for Optimal Treatment Response
110403 -
110404 - Millie's treatment history on 090121 indicates she does not have a lot
110405 - treatments left. ref SDS 7 H16M
110407 -  ..
110408 - Millie has requested 2nd opinion support from Doctor Stritter for
110409 - treatments that can help her in the future, shown by the scope of work
110410 - on 090106. ref SDS 6 PQ6Q
110412 -  ..
110413 - An attractive solution is to obtain a specimen of Millie's cancer and
110414 - test in the laboratory to discover treatments that are effective,
110415 - before investing a lot of time and money getting treatments and then
110416 - discover they are not effective. (added to Stritter scope on 090106,
110417 - ref SDS 6 E55M)
110418 -
110419 -            [On 090204 request opinion on viability and sources for
110420 -            testing cancer to determine best treatment modality.
110421 -            ref SDS 15 FQ3W
110423 -  ..
110424 - Research today shows this was at one time tried, and now is not
110425 - approved by the FDA...
110426 -
110427 -        Breastcancer.org
110428 -        Discussion Boards
110429 -
110430 -              http://community.breastcancer.org/member/77404/profile
110432 -         ..
110433 -        Jan 9, 2009 11:02 pm   cornfieldheiress wrote:
110435 -         ..
110436 -        There used to be clinics in States that tested for chemo
110437 -        tolerance -fda has shut most of them down so you have to go
110438 -        offshore.  When I was diagnosed with ibc, we sent my blood to
110439 -        Athens Greece:
110440 -
110441 -            [On 090204 request opinion on viability and sources for
110442 -            testing cancer to determine best treatment modality.
110443 -            ref SDS 15 FQ3W
110445 -         ..
110446 -        Research.Genetic.Cancer.Centre.
110447 -
110448 -        Dr. Papasotiriou Ionnis MD
110450 -         ..
110451 -        115 M.Alexandrou str
110453 -         ..
110454 -        53070 FilotasFlorina
110456 -         ..
110457 -        Griechenland-Greece.
110459 -         ..
110460 -        You send your blood to their laboratories and they will tell
110461 -        you which chemos work in your body.  Not all docs are open to
110462 -        this, of course.  Some doctors are paid rebates for using
110463 -        certain chemos, I'm sorry to say.  Anyway,you wire money to the
110464 -        clinic along with your bloodwork which are sent DHL I believe;
110465 -        I paid 1800.00.  Results are quick-within a few days.
110466 -
110467 -
110468 -
110469 -
110470 -
110471 -
110472 -
110473 -
110474 -
110475 -
1105 -