CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 4 465H.
040502 -
040503 -
040504 -
040506 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Jackie called this morning and reported that Doctor Rugo was
040902 - successful getting approval from the clinical trial sponsors to change
040903 - frequency of CT tests from 8 to 12 weeks, as requested in Millie's
040904 - letter to the doctor on 071007. ref SDS 4 465H
040906 -  ..
040907 - Millie submitted a letter confirming this understanding, and
040908 - saying...
040909 -
040910 -    1.  Subject: CT Tests Changed to 12 Week Intervals
040911 -        Date: Tue, 09 Oct 2007 11:57:41 -0700
040918 -         ..
040919 -    2.  Dear Doctor Rugo,
040921 -         ..
040922 -    3.  Jackie called earlier today and advised (she talked to Rod)
040923 -        that you were successful changing CT testing from 8 to 12 week
040924 -        intervals, as discussed in the letter on 071007. ref SDS 4 465H
040926 -  ..
040927 - This change gives Millie more time for recovering from injury caused
040928 - by multiple needle penetrations to inject CT test contrast medium,
040929 - which was taking 3 to 4 attempts over several hours, was very painful,
040930 - ref SDS 2 5G5J, and caused significant trauma to Millie's right arm,
040931 - reported on 071004. ref SDS 3 DE62
040932 -
040933 -            [On 080207 Millie's IBC seemed to be relapsing; doctor
040934 -            ordered return to more frequent testing on 8 week schedule
040935 -            required by clinical trial protocol. ref SDS 5 GH5M
040937 -             ..
040938 -            [On 080212 Millie had CT test at Kaiser; technician did a
040939 -            good job making only a few mistakes finding a vein to
040940 -            inject contrast media. ref SDS 6 FP5H
040942 -             ..
040943 -            [On 080425 CT test required 4 needle penetrations and took
040944 -            over 3 hours, very painful because of difficulty finding a
040945 -            vein to inject contrast medium. ref SDS 7 FP6F
040946 -
040947 -
040949 -  ..
040950 - IBC Intensity Possible Rising then Subsiding
040951 -
040952 -
040953 -    4.  Jackie and Rod also discussed possible increased intensity of
040954 -        IBC rash observed yesterday.
040956 -         ..
040957 -    5.  This is subjective, but there may be some increased intensity
040958 -        of IBC that occurs in a small area of the inner right breast,
040959 -        and a line of rash across the upper left chest.  There is no
040960 -        indication of expanding rash.  As well, the rash on the left
040961 -        arm seemed more intense yesterday.  This was all after a
040962 -        shower, so that may have been a factor, as well as inflammation
040963 -        caused by cetuximab, noted in the protocol received on 070116.
040964 -        ref SDS 1 MH4Q
040966 -         ..
040967 -    6.  Today, I just checked, and it seems possibly less intense, so
040968 -        go figure.  My feeling is that we can wait until the regularly
040969 -        scheduled meeting next week to check this out.  But Jackie,
040970 -        said we should keep a close eye on it for significant change.
040972 -         ..
040973 -    7.  Thanks again for revising the CT test frequency.
040981 -         ..
040982 -   10.  PS.  When time permits, please comment on HER2 status change
040983 -        and Herceptin issue, also, submitted on 071007. ref SDS 4 S68T
040984 -
040985 -             [...below, the doctor responds. ref SDS 0 HH4W
040986 -
040987 -
040989 -  ..
0410 -
0411 -
0412 - 1441
0413 -
041301 - Millie received a letter from Doctor Rugo responding to her letter
041302 - this morning proposing plans to examin possible rising cancer, per
041303 - above. ref SDS 0 985H
041304 -
041305 -    1.  Subject:  CT Tests Changed to 12 Week Intervals
041306 -        Date: Tue, 9 Oct 2007 13:08:37 -0700
041313 -         ..
041314 -    2.  sounds like a good plan Millie, thanks for updating me.
041316 -         ..
041317 -    3.  your tumor is HER2 negative, the cutoff is still 2!
041319 -  ..
041320 - The doctor responds to the request today, per above, ref SDS 0 I44R,
041321 - citing the letter on 071007 reporting from recent support group
041322 - presentation suggesting HER2 negative criteria may have changed from 2
041323 - to 1.5. ref SDS 4 S68T
041324 -
041325 -            [On 080207 the Doctor asks investigating status change to
041326 -            assess options for treating Millie's relapse. ref SDS 5
041327 -            6S6G
041328 -
041329 -
041330 -
041331 -
041332 -
041333 -
041334 -
0414 -