THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: March 29, 2005 09:00 AM Tuesday; Rod Welch

Meeting at Kaiser doctor changes treatment plan due to worsening IBC.

1...Summary/Objective
2...Agenda for Work Plan After 2 Treatments of AC
3...CA 15-3 Cancer Marker 100 Rises Dramatically to Dangerous Level
4...CA 15-3 100 Cancer Marker Rises Again Signaling IBC Worsens
5...IBC Progressing Clinical Symptoms Rise Aligns with Rising CA 15-3
6...CT Scan Test Results Not Available
7...MUGA Test Not Available Evaluate Heart Damage from AC Treatments
8...Pulmonary Emoboli Symptoms End Treatment with Coumadin Continue
9...Coumadin Treatment Continues for Pulmonary Emoboli after Symptoms End
10...Lumps Under Arm Seems Unchanged
11...Lumps in Neck No Evidence of Swelling Indicating Cancer Receded
12...Wound Biopsy Beginning to Heal Treatment with Adriamycin Cytoxan AC
13...IBC May be Less Intense Hard to Remember Spread of Disease Not Good
14...Cancer Sores Left Breast Blistering IBC with AC Treatment Slow Improve
15...Blistering Sores Cancer Left Breast IBC Slow Improve with AC Treatment
16...Redness IBC Spreads Rising CA 15-3 Slow Progress AC Change Treatment
17...Hectic Schedule Report on Surgeon Examination Pending Review
18...Examination by Surgeon Recommends Healing IBC Prior to Surgery
19...Surgeon Most Experienced Performing Mastectomy Procedures
20...Adriamycin Cytoxan AC Treatment Stopped
21...Treatment Plan Change Chemotherapy from AC to Taxotere Capeticabine
22...Taxotere Capeticabine (Xeloda) Chemotherapy under New Treatment Plan
........Side Effects Peeling Blisters on Feet Hands


..............
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CONTACTS 

SUBJECTS
Meeting Doctor Assess Treatment Review Progress Substantially Rising

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 58 0000. ref SDS 53 0000.
040502 -
040503 - CA 15-3 jumped significantly again this cycle to over 100, possibly
040504 - due to missed treatments that reduced concentration of AC; signals
040505 - need for action. ref SDS 0 GJ5M  CT test results were not available,
040506 - but expected to continue showing no distant metastasis, even though
040507 - IBC is advancing. ref SDS 0 NL4N  MUGA test was not avilable for the
040508 - meeting; since AC treatment was stopped today, this is not
040509 - significant. ref SDS 0 IL7F  Biopsy wound shows healing, but IBC has
040510 - not significantly improved under treatment with AC. ref SDS 0 025H
040511 - Surgeon's examination and comments were reviewed indicating that
040512 - mastectomy requires clearing the left breast of disease prior to
040513 - surgery. ref SDS 0 XQ41  Treatment was changed from AC to Taxotere and
040514 - capecitabine (Xeloda). ref SDS 0 T58M
040515 -
040516 -            [On 050502 visual improvement sores and inflamation are
040517 -            receding, ref SDS 69 EO5J
040519 -             ..
040520 -            [On 050510 further improvement inflammation (redness) seems
040521 -            entirely gone, and softness has returned to the breast.
040522 -            ref SDS 70 EO5J
040524 -             ..
040525 -            [On 050520 dramatic improvement after 2 cycles of treatment
040526 -            with Taxotere and Xeloda. ref SDS 73 R19I
040527 -
040528 -
040529 -
040530 -
040532 -  ..
0406 -
0407 -
0408 - Discussion
0409 -
040901 - Agenda for Work Plan After 2 Treatments of AC
040902 -
040903 - Follow up ref SDS 58 SM6M, ref SDS 53 SM6M.
040905 -  ..
040906 - Millie created an agenda on the marking board...
040907 -
040908 -        CA 15-3 dramatic rise...................... ref SDS 0 GJ5M
040909 -        CT test results............................ ref SDS 0 NL4N
040910 -        MUGA test results to continue AC........... ref SDS 0 IL7F
040911 -        Wound punch biopsy better.................. ref SDS 0 6T5G
040912 -        Breast exam worsening IBC.................. ref SDS 0 025H
040913 -        Surgeron examination report................ ref SDS 0 XQ41
040914 -        Treatment plan............................. ref SDS 0 AW5G
040915 -
040916 -
040917 -
040918 -
040919 -
0410 -

SUBJECTS
CA 15-3 100 Down from 105 Substantially Up from 88 in 3 Weeks Aligns

1203 -
120401 -  ..
120402 - CA 15-3 Cancer Marker 100 Rises Dramatically to Dangerous Level
120403 -
120404 - Follow up ref SDS 58 087J, ref SDS 53 087J.
120405 -
120406 - Blood test on 050325 shows CA 15-3 dropped to 100 from the prior test
120407 - on 050318 which increased to 101 from 88 reported on 050325,
120408 - ref SDS 63 2N5J, continuing a rise from 95 reported three (3) weeks
120409 - ago on 050308, and cited a few days later during the meeting on
120410 - 050311. ref SDS 58 087J
120412 -           ..
120413 -          050325.........100 H............. 050329, ref SDS 0 087J
120414 -          050318.........101 H............. 050325, ref SDS 63 2N5J
120415 -          050304......... 88 H............. 050311, ref SDS 58 087J
120416 -          050225......... 95 H............. 050308, ref SDS 57 0001
120417 -          050211......... 78 H............. 050214, ref SDS 55 02BB
120418 -          050128......... 67 H............. 050204, ref SDS 53 087J
120419 -          041228......... 56 H............. 041230, ref SDS 48 087J
120420 -          041204......... 43 H............. 041210, ref SDS 45 087J
120421 -          041007......... 39............... 041104, ref SDS 38 087J
120422 -          040923......... 49 H............. 041005, ref SDS 36 087J
120423 -          040908......... 44 H............. 040909, ref SDS 35 087J
120424 -          040825......... 47 H............. 040812, ref SDS 35 087J
120425 -          040811......... 42 H............. 040812, ref SDS 34 087J
120426 -          040728......... 43 H............. 040729, ref SDS 33 2N5J
120427 -          040712......... 47 H............. 040713, ref SDS 32 087J
120428 -          040614......... 55 H............. 040615, ref SDS 31 PX6X
120429 -          040517......... 78 H............. 040601, ref SDS 30 2N5J
120430 -          040311......... 70 H............. 040318, ref SDS 27 SM6M
120431 -          040205......... 60 H............. 040211, ref SDS 26 SM6M
120432 -          031201......... 62 H............. 031205, ref SDS 25 SM6M
120433 -          030912......... 66 H............. 030915, ref SDS 24 SM6M
120434 -          030708......... 68 H............. 030710, ref SDS 23 SM6M
120435 -          030503......... 54 H............. 030508, ref SDS 21 SM6M
120436 -          030403......... 45 H............. 030508, ref SDS 21 SM6M
120437 -          030215......... 46 H............. 030220, ref SDS 20 5E6L
120438 -          030106......... 37 H............. 030109, ref SDS 19 SM6M
120439 -          021202......... 41 H?............ 021204, ref SDS 18 SP5G
120440 -          021111......... 36 H?............ 021113, ref SDS 17 Y65I
120441 -          021023......... 33 H?............ 021023, ref SDS 16 SQ5I
120442 -          020930......... 33 H?..29........ 021002, ref SDS 15 SQ5I
120443 -          020917......... 36 H?............ 020924, ref SDS 14 SQ5I
120444 -          020717......... 59 H?............ 020726, ref SDS 13 YN5K
120445 -          020629......... 75 H ............ 020705, ref SDS 12 UX6I
120446 -          020608........  67 H ............ 020614, ref SDS 11 0001
120447 -          020603........ 108 H ............ 020607, ref SDS 10 X67F
120448 -          020511........ 117 H ............ 020603, ref SDS 9 PJ4J
120449 -          020419......... 81 H ............ 020430, ref SDS 8 7N5H
120450 -          020321......... 85 H ............ 020405, ref SDS 7 6T8K
120451 -
120452 -
120454 -  ..
1205 -
1206 -
1207 - Analysis
1208 -
120801 - CA 15-3 100 Cancer Marker Rises Again Signaling IBC Worsens
120802 - IBC Progressing Clinical Symptoms Rise Aligns with Rising CA 15-3
120803 -
120804 - Follow up ref SDS 58 GJ5M, ref SDS 53 GJ5M.
120805 -
120806 - On 050316 treatment was deferred again because white blood cell count
120807 - was much too low. ref SDS 60 0001  On 050324 the surgeon found
120808 - worsening IBC. ref SDS 61 YY7F
120810 -  ..
120811 - The doctor feels today that this record of worsening IBC symptoms,
120812 - discussed below, ref SDS 0 025H, aligns with CA 15-3 rising
120813 - substantially from 78 on 050214 to over 100 under the current
120814 - treatment plan using AC, initially prescribed for two (2) treatments
120815 - on 041230, ref SDS 48 XQ41, and later extended on 050311, ref SDS 58
120816 - J544, after plans to change treatment if CA 15-3 continues rising,
120817 - discussed with Millie in the hospital on 050214. ref SDS 55 W58T  On
120818 - 030710 the doctor indicated CA 15-3 above 80 signaled consideration to
120819 - change course. ref SDS 23 WS42
120820 -
120821 -     [On 050520 dramatic improvement CA 15-3 falls from 105 to 67 after
120822 -     2 cycles of treatment with Taxotere and capecitabine (Xeloda).
120823 -     ref SDS 72 GJ5M
120824 -
120825 -
120826 -
120827 -
120828 -
1209 -

SUBJECTS
CT Test Report Not Available for Meeting Today to Evaluate Distant M

1303 -
130401 -  ..
130402 - CT Scan Test Results Not Available
130403 -
130404 - Follow up ref SDS 58 NL4N, ref SDS 53 NL4N.
130405 -
130406 - Results were not available today for CT test on 050325, ref SDS 62
130407 - 0001, scheduled on 050311 to evaluate new cancer sores and rising CA
130408 - 15-3 cancer marker. ref SDS 58 NL4N
130410 -  ..
130411 - The Doctor called a telephone number to get a verbal report on test
130412 - results.  There was a message saying the report for Millie's test has
130413 - not yet been posted by the analyst.  Though the report was not
130414 - available, analysis of other diagnostics suggest advancing IBC
130415 - activity, ref SDS 0 025H, which does not register strongly in CT
130416 - testing.  There was nothing in the examination today that suggests
130417 - distant metastasis, consistent with prior CT test results, e.g., on
130418 - 041230. ref SDS 48 NL4N
130419 -
130420 -
130421 -
130422 -
130423 -
1305 -

SUBJECTS
MUGA Test on Heart for Continuing AC Chemotherapy Treatments Results

1603 -
160401 -  ..
160402 - MUGA Test Not Available Evaluate Heart Damage from AC Treatments
160403 -
160404 - Follow up ref SDS 64 0001, ref SDS 58 9Z4N,.
160405 -
160406 - The doctor advised that results of the MUGA test on 050328 have not
160407 - yet been reported for evaluating heart damage from continuing AC
160408 - treatments, ref SDS 64 0001, which was planned during the meeting on
160409 - 041230. ref SDS 48 XQ84,
160410 -
160411 -
160412 -
160413 -
160414 -
160415 -
160416 -
160417 -
1605 -

SUBJECTS
Pulmonary Emoboli Symptoms End Treatment with Coumadin Continue

2303 -
230401 -  ..
230402 - Pulmonary Emoboli Symptoms End Treatment with Coumadin Continue
230403 - Coumadin Treatment Continues for Pulmonary Emoboli after Symptoms End
230404 -
230405 - Follow up ref SDS 58 RZ4I, ref SDS 53 RZ4I.
230406 -
230407 - No discussion again during this meeting to carry out review based on
230408 - planning during the meeting on 050204 to assess Coumadin requirements
230409 - in a few months time. ref SDS 53 S34O
230411 -  ..
230412 - No symptoms pulmonary emboli, blood clots.
230413 -
230414 -
230415 -
230416 -
230417 -
2305 -

SUBJECTS
Arm Lumps Lymph Nodes Swelled Under Left Side No Examination Patient

2503 -
250401 -  ..
250402 - Lumps Under Arm Seems Unchanged
250403 -
250404 - Follow up ref SDS 58 MW8J, ref SDS 53 MW8J.
250405 -
250406 - There was no examination and no discussion of lump under the arm due
250407 - to focus on new problems in the left breast.
250408 -
250409 -
250410 -
250411 -
2505 -

SUBJECTS
Neck Lumps Lymph Nodes Left Side No Examination Patient Reports Favo

3003 -
300401 -  ..
300402 - Lumps in Neck No Evidence of Swelling Indicating Cancer Receded
300403 -
300404 - Follow up ref SDS 58 8R6M, ref SDS 53 8R6M.
300405 -
300406 - No examination of the neck, because of prior favorable examinations
300407 - and testing the past few months, illustrated by the report on 041104.
300408 - ref SDS 38 8R6M
300409 -
300410 -
300411 -
300412 -
3005 -

SUBJECTS
Wound Punch Biopsy Left Breast Healing Improves after 4 Treatments w

3703 -
370401 -  ..
370402 - Wound Biopsy Beginning to Heal Treatment with Adriamycin Cytoxan AC
370403 -
370404 - Follow up ref SDS 58 6T5G, ref SDS 53 6T5G.
370405 -
370406 - The doctor examined the left breast and noted slow, steady healing of
370407 - the punch biopsy wound since examination on 050311, and following the
370408 - 4th treatment of chemotherapy for IBC with AC on 050325. ref SDS 63
370409 - KR30
370411 -  ..
370412 - This aligns with the surgeon's comments on 050324 finding marked
370413 - improvement healing the biopsy wound, ref SDS 61 906K, since the
370414 - examination on 050107.
370415 -
370416 -
370417 -
370418 -
370419 -
370420 -
370421 -
3705 -

SUBJECTS
IBC Cancer Sores Blister Left Breast Redness IBC Spreads Slow Recove
IBC Worsens Cancer Sores Begin to Blister on Left Breast Redness IBC

4304 -
430501 -  ..
430502 - IBC May be Less Intense Hard to Remember Spread of Disease Not Good
430503 - Cancer Sores Left Breast Blistering IBC with AC Treatment Slow Improve
430504 - Blistering Sores Cancer Left Breast IBC Slow Improve with AC Treatment
430505 -
430506 - Follow up ref SDS 58 025H, ref SDS 53 025H.
430508 -  ..
430509 - Redness IBC Spreads Rising CA 15-3 Slow Progress AC Change Treatment
430511 -  ..
430512 - The doctor commented that red coloration from IBC inflammation seems
430513 - less intense today, but it is hard to remember after seeing so many
430514 - patients since the prior examination on 050311.  The spread of redness
430515 - above the breast, along with cancer sores observed is not good.  This
430516 - aligns the surgeon's examination a few days ago on 050324, ref SDS 61
430517 - YY7F  The doctor cited rising CA 15-3 cancer marker, now at 100,
430518 - indicates treatment is not achieving results, based on prior
430519 - experience reported by the doctor on 030710, ref SDS 23 WS42, and
430520 - discussed again today, per above. ref SDS 0 GJ5M
430522 -  ..
430523 - The doctor feels treatment should be changed, discussed below.
430524 - ref SDS 0 AW5G
430526 -      ..
430527 -     [On 050502 visual improvement sores and inflamation are receding,
430528 -     ref SDS 69 EO5J
430530 -      ..
430531 -     [On 050510 further improvement inflammation (redness) seems
430532 -     entirely gone, and softness has returned to the breast.
430533 -     ref SDS 70 EO5J
430535 -      ..
430536 -     [On 050520 dramatic improvement after 2 cycles of treatment with
430537 -     Taxotere and Xeloda. ref SDS 73 R19I
430538 -
430539 -
430540 -
430541 -
430542 -
4306 -

SUBJECTS
Management Standards Healthwise Handbook Communication Collaboration
Hectec Busy Being Busy Not Enough Time to Think Continual Bumbling I
Patient Organize Medical Record Organizational Memory Critical Facto
Surgery Examination on 050324 to Evaluate Readiness for Masectomy Pr

7006 -
700701 -  ..
700702 - Hectic Schedule Report on Surgeon Examination Pending Review
700703 - Examination by Surgeon Recommends Healing IBC Prior to Surgery
700704 -
700705 - Follow up ref SDS 58 XQ41, ref SDS 53 XQ41.
700706 -
700707 - The doctor asked about results of meeting with the surgeon on 050324
700708 - to consider a mastectomy for treating "pockets of resistance" to
700709 - chemotheapy? ref SDS 61 GK9M
700711 -  ..
700712 - Background on considerations for surgery in this case are summarized
700713 - on 041210, ref SDS 45 ZV5J, and case study to extend quality of life
700714 - by preventing disease from cascading out of control is reported on
700715 - 041230. ref SDS 48 XV7M
700717 -  ..
700718 - Millie asked about the surgeon's report to Oncology, planned in the
700719 - meeting on 050324? ref SDS 61 ER7F
700721 -  ..
700722 - The doctor said things have been hectic, similar to the report on
700723 - 020726, ref SDS 13 SQ5I, and, as a result, there has not been time for
700724 - the Oncology Department to collaborate with the surgeon in the manner
700725 - planned on 041230, ref SDS 48 UJ5M, nor to look for the Surgeon's
700726 - report on Millie's case, and make a review of the meeting last week in
700727 - order to prepare for the meeting today under Team Care practice,
700728 - discussed previously on 050311. ref SDS 58 PB6J
700729 -
700730 -     [On 050727 due diligence discussed with surgeon to collaborate and
700731 -     communicate through Team Care for leveraging experience with a
700732 -     Tumor Board and investigating among colleagues and experts for
700733 -     treating IBC, which is a rare disease for which experience is very
700734 -     limited among daily practioners. ref SDS 76 O85O
700736 -      ..
700737 -     [On 050824 Advice Nurse in Surgery Department expects surgeon
700738 -     applied Team Care practice to collaborate with a referral doctor
700739 -     in Kaiser's Oakland office by providing background and explaining
700740 -     patient history so that the referral doctor can be prepared to
700741 -     conduct a productive meeting with the patient. ref SDS 78 HX48
700743 -      ..
700744 -     [On 050826 referral doctor in Oakland was not familiar with Kaiser
700745 -     organizational memory on patient history; background submitted
700746 -     during the meeting was described as the only summary available, as
700747 -     helpful, but was too late for the doctor to be prepared, so the
700748 -     entire meeting was based on recollections of personal memory.
700749 -     ref SDS 79 BL8N
700751 -  ..
700752 - This aligns with reporting on 970910 that people do not have enough
700753 - time to think due to a hectic schedule. ref SDS 2 3479  Previously,
700754 - Kissinger noted that limited time reduces analysis, reviewed on
700755 - 940609. ref SDS 1 4238  Hurrying under duress of limited time was
700756 - cited in the study on 990912 explaining the high cost of medical
700757 - mistakes. ref SDS 5 0285
700759 -  ..
700760 - The doctor asked again today for patient impressions from meeting the
700761 - surgeon on 050324, repeating the process used during the meeting on
700762 - 050204, ref SDS 53 RD3M, to get results on the surgeon's prior
700763 - examination on 050107.
700765 -  ..
700766 - Millie related the surgeon's reluctance to perform surgery for a
700767 - masectomy on the left breast until disease is fully cleared from the
700768 - site, reported on 050324. ref SDS 61 WH5L
700769 -
700770 -     [On 050727 follow up examination by surgeon shows biopsy wound
700771 -     fully healed, and IBC has healed sufficiently for surgery after 4
700772 -     treatments with Taxotere and capecitabine. ref SDS 76 CK7N
700774 -      ..
700775 -     [On 050729 doctor asks about results of surgeon's examination on
700776 -     050727, and schedule for performing surgery pending due diligence
700777 -     on criteria. ref SDS 77 XQ41
700779 -  ..
700780 - The doctor asked about discussion of criteria for surgery, from
700781 - planning on 050311? ref SDS 58 PB4N
700783 -  ..
700784 - Millie recalled there was discussion with the surgeon on 050324 about
700785 - criteria for performing masectomy; details are hard to remember, and
700786 - are set out in the record of the meeting on 050324. ref SDS 61 OV5H
700788 -  ..
700789 - The doctor plans to talk with the surgeon on this.
700790 -
700791 -     [On 050401 Millie and Pam met with Doctor Choi who recommended
700792 -     against surgery at this time; there was no evident discussion on
700793 -     criteria that establish level of recovery where surgery can be
700794 -     performed. ref SDS 66 PPSU
700796 -      ..
700797 -     [On 050727 surgeon reported there have not yet been discussions
700798 -     with the primary care physician on Millie's case. ref SDS 76 OV5H
700799 -
700800 -
700801 -
700802 -
7009 -

SUBJECTS
Surgeon Experienced Mastectomy Procedures Best in Kaiser Walnut Cree

7203 -
720401 -  ..
720402 - Surgeon Most Experienced Performing Mastectomy Procedures
720403 -
720404 - Millie cited concerns by the surgeon on 050324 having limited
720405 - experience performing surgery for a masectomy on a patient with IBC,
720406 - and particularly, where the doctor proposes to treat "pockets of
720407 - resistance" to chemotherapy with surgery, ref SDS 61 QJ3Q, requested
720408 - for consideration by the doctor during the meeting on 050311.
720409 - ref SDS 58 PA4N
720411 -  ..
720412 - The doctor commented today that Millie is fortunate because the
720413 - surgeon who made the examination and consultation on 050324 is the
720414 - most experienced surgeon in the Walnut Creek, CA hospital and clinic.
720415 -
720416 -     [On 050401 Doctor Choi concurred with this assesment. ref SDS 66
720417 -     PPVP
720419 -      ..
720420 -     [On 050727 follow up examination by surgeon shows biopsy wound
720421 -     fully healed, and IBC has healed sufficiently for surgery after 4
720422 -     treatments with Taxotere and capecitabine. ref SDS 76 CK7N
720424 -      ..
720425 -     [On 050928 Doctor Smith commends surgeon's commitment to patient
720426 -     care, and strong feelings for Millie's case. ref SDS 81 258K
720427 -
720428 -
720429 -
720430 -
720431 -
720432 -
720433 -
720434 -
720435 -
7205 -

SUBJECTS
Adriamycin Cytoxan AC 2 Cycles Doctor Prescribes Additional Cycles a
Treatment Plan End Adriamycin Cytoxan AC after 6 Total Treatments Ch
Chemotherapy Not Effective New Blood Test Orderded Changed Treatment
Adriamycin Cytoxan AC Ended after 6 Total Treatments New Treatment P

8306 -
830701 -  ..
830702 - Adriamycin Cytoxan AC Treatment Stopped
830703 - Treatment Plan Change Chemotherapy from AC to Taxotere Capeticabine
830704 - Taxotere Capeticabine (Xeloda) Chemotherapy under New Treatment Plan
830705 -
830706 - Follow up ref SDS 58 J53N, ref SDS 48 XQ41.
830707 -
830708 - The doctor reviewed analysis on 050311, ref SDS 58 7B4F, which led to
830709 - planning that continued treatment with AC, rather than switch to
830710 - Taxol, Taxotere, Capacitabine, etc. ref SDS 58 J53N
830712 -  ..
830713 - The doctor cited difficulty maintaining a consistant level of medicine
830714 - in the patient's body, due to deferred treatments on 050316,
830715 - ref SDS 60 0001, and previously on 050225, ref SDS 56 407N  This
830716 - reduced concentration of AC chemotherapy may be causing slow response
830717 - to the current regimen begun on 050104, ref SDS 50 0001, to implement
830718 - planning on 041230, ref SDS 48 XQ41, and then amended on 050204,
830719 - adding two (2) additional treatments with AC. ref SDS 53 XQ41
830721 -  ..
830722 - Millie asked about changing treatment to improve results by switching
830723 - to a different chemotherapy regimen listed in planning on 041230 to
830724 - try Taxol, Taxotere, capeticabine, etc. ref SDS 48 Y37T
830726 -  ..
830727 - Since recovery is slow, and IBC may be worsening, found by the surgeon
830728 - on 050324, again by the doctor today, ref SDS 0 025H, and indicated by
830729 - CA 15-3 rising to 100, per above, ref SDS 0 GJ5M, the doctor proposed
830730 - the following change to try a new work plan...
830731 -
830732 -    a.  AC will be discontinued after 6 cycles today to prevent cancer
830733 -        from getting worse, under reasoning on 041230. ref SDS 48 XQ84
830734 -        This avoids further concern about impact of 6 AC treatments on
830735 -        the heart, reviewed on 050204. ref SDS 53 M46G  Results of the
830736 -        MUGA test are not available, but since CA 15-3, coloration and
830737 -        sores on the breast indicate that AC may not be effective
830738 -        enough to reach a point that permits mastectomy surgery, a
830739 -        change improves chances of recovery for the patient and
830740 -        prevents disease from cascading out of control, discussed by
830741 -        the doctor, also, on 041230. ref SDS 48 P19O
830742 -
830743 -            [On 050422 MUGA test report shows no evidence heart damage.
830744 -            ref SDS 68 UG4H
830746 -         ..
830747 -    b.  Taxotere and capecitabine (Xeloda) couplet will be tried,
830748 -        beginning in three (3) weeks on 050415.  This maintains current
830749 -        treatment schedule, but switches from AC to the new treatment
830750 -        recommended by Doctor Benze at UCSF in a 2nd opinion received
830751 -        on 041117, ref SDS 39 OU6S, and discussed with the doctor at
830752 -        Kaiser on 041130. ref SDS 40 5X4J  Today, the doctor scheduled
830753 -        four (4) cycles with Millie getting Taxotere every three weeks.
830754 -        In addition she will ingest two (2) pills of capecitabine
830755 -        (Xeloda) twice a day for two (2) weeks beginning the day of
830756 -        treatment with Taxotere.  She will then have a one week rest,
830757 -        before starting the next cycle of Taxotere on the 3rd week.
830758 -
830759 -            [On 050913 doctor objects that 2nd opinions delay
830760 -            mastectomy surgery for patient with secondary IBC, history
830761 -            of relapse, and pulmonary emboli. ref SDS 80 G44O
830763 -             ..
830764 -            [On 061208 doctor objects to multi-agent, couplets
830765 -            combining chemotherapy drug treatments. ref SDS 83 HS5O
830767 -         ..
830768 -        This implements review on 041230 citing advantage of taxaine
830769 -        for Millie's patient profile, ref SDS 48 2V85, and analysis of
830770 -        treatment plan, also, on 041230. ref SDS 48 D49F
830772 -         ..
830773 -        The goal is positive response that permits surgery, per visit
830774 -        with surgeon on 050324. ref SDS 61 WH5L
830775 -
830776 -            [On 050415 treatment begins with new chemotherapy protocol
830777 -            Taxotere and capecitiabine (Xeloda). ref SDS 67 407N
830778 -
830779 -            [On 050502 marked improvement after 2 weeks of treatment
830780 -            with Taxotere and capecitabine (Xeloda), IBC significantly
830781 -            subsides. ref SDS 69 EO5J
830783 -             ..
830784 -            [On 050510 further improvement inflammation (redness) seems
830785 -            entirely gone, and softness has returned to the breast.
830786 -            ref SDS 70 EO5J
830788 -             ..
830789 -            [On 050520 dramatic improvement after 2 cycles of treatment
830790 -            with Taxotere and capecitabine (Xeloda), ref SDS 72 025H,
830791 -            despite temporarily stopping treatments beginning on 050514
830792 -            due to severe side effects, ref SDS 71 RU9M; on 050520
830793 -            treatment dose for capecitabine (Xeloda) reduced to reduce
830794 -            side effects. ref SDS 72 NT3I
830796 -             ..
830797 -            [On 050610 recovery from IBC continues with reduced dose of
830798 -            capecitabine (Xeloda) beginning 4th cycle. ref SDS 74 025H
830800 -             ..
830801 -            [On 051007 PET scan test reports no evidence of local,
830802 -            regional, nor local cancer after 8 cycles of treatment with
830803 -            Taxotere and capecitabine. ref SDS 82 L66M
830804 -
830805 -
830807 -         ..
830808 -        Side Effects Peeling Blisters on Feet Hands
830809 -
830810 -        Doctor explained possible effects that hands and feet
830811 -        may show some redness.  The doctor advised that
830812 -        Millie will get a call from the pharmacist to
830813 -        schedule a meeting for review of all side effects and
830814 -        to prescribe medications that reduce problems due to
830815 -        side effects.
830816 -
830817 -            [On 050415 pharmacist met with Millie in the
830818 -            clinic while she was getting the first day of new
830819 -            chemotherapy treatments. ref SDS 67 7F8Q
830821 -             ..
830822 -            [On 050510 Millie experienced pain hands and
830823 -            feet. ref SDS 70 DX54
830825 -             ..
830826 -            [On 050520 dramatic improvement after 2 cycles of treatment
830827 -            with Taxotere and capecitabine (Xeloda), ref SDS 72 025H,
830828 -            despite temporarily stopping treatments beginning on 050514
830829 -            due to severe side effects, ref SDS 71 RU9M; on 050520
830830 -            treatment dose for capecitabine (Xeloda) reduced to reduce
830831 -            side effects. ref SDS 72 NT3I
830833 -             ..
830834 -            [On 050610 recovery from IBC continues with reduced dose of
830835 -            capecitabine (Xeloda). ref SDS 74 025H
830836 -
830837 -
830838 -
830839 -
830840 -
830841 -
830842 -
8309 -