Kaiser Permanente
Permanente Medical Group, Inc.
1425 South Main Street
Walnut Creek, CA 94596
925 295 4000



December 29, 2006 1656

08 02 04 60 06122901




Millie

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Subject:   Kaiser Answer Questions UCSF Letter 061229

Dear Millie,

This is the message from Dr. Rugo. My responses are in brackets. I woul hold Gemzar for now because it may otherwise disqualify you for one of these studies:
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I think she has had three lines of therapy and therefore would still qualify for the cetuximab trial, could you confirm if this is true? (This is true)
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Is she doing well performance status wise, and is stable on anticoagulation? (Yes.)
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Did the new PE occur on full anticoagulation or not? (She was off wafarin because a year had past, she was off Avastin, and her disease was relatively inactive for a while after her mastectomy.)
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I assume she has ER/PR/HER2 (Yes)- disease, we also have a phase one trial of avastin and abraxane that she would qualify for as well, and she could do that if the cetuximab/carboplatin combination was not effective.
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I assume also that her disease is emeasurable (only elevated CA 15-3 and equivocal findings on PET), and that she could go on a trial that woudl be supported by Kaiser or some other insurer?
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(Yes, for any costs not covered by the trial)
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Our trials are funded, but do not cover standard of care.
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(Should we arrange for her to see you or Dr. Benz again??)

Sincerely,



[Primary care physician]